simple synthesis and biological evaluation of some benzimidazoles using sodium hexafluroaluminate, na3alf6, as an efficient catalyst

Authors

akbar mobinikhaledi department of chemistry, faculty of science, arak university, arak 38156-8-8349, iran.

ahmad hamta department of biology, , faculty of science, arak university, arak 38156-8-8349, iran.

mehdi kalhor department of chemistry, faculty of science, payam noor university.

mehdi shariatzadeh department of biochemistry, shiraz university, shiraz, iran.

abstract

considerable attention has been focused on the synthesis of benzimidazoles due to having a broad spectrum of biological activities such as anti-parasitic, fungicidal, anti-thelemintic and anti-inflammatory activities. as a part of our research work in this area, a series of benzimidasole derivatives (3a-n) were synthesized in good to high yields by reaction of o-phenylenediamine and different aromatic aldehydes in the presence of sodium hexafluroaluminate, na3alf6, as an efficient catalyst at 50 ◦c. this environmentally benign and practical method offers several advantages, such as high yields, use of available catalyst, mild reaction conditions and easy workup. the antibacterial activity of these benzimidasoles was also evaluated using staphylococcus aureus (mm) and escherichia coli (mm) bacterial strain. all synthesized materials were characterized using ir and nmr spectroscopy as well as microanalyses data.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na3AlF6, as an Efficient Catalyst

Considerable attention has been focused on the synthesis of benzimidazoles due to having a broad spectrum of biological activities such as anti-parasitic, fungicidal, anti-thelemintic and anti-inflammatory activities. As a part of our research work in this area, a series of benzimidasole derivatives (3a-n) were synthesized in good to high yields by reaction of o-phenylenediamine and different a...

full text

Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na3AlF6, as an Efficient Catalyst

Considerable attention has been focused on the synthesis of benzimidazoles due to having a broad spectrum of biological activities such as anti-parasitic, fungicidal, anti-thelemintic and anti-inflammatory activities. As a part of our research work in this area, a series of benzimidasole derivatives (3a-n) were synthesized in good to high yields by reaction of o-phenylenediamine and different a...

full text

Simple Synthesis and Biological Evaluation of Some Benzimidazoles Using Sodium Hexafluroaluminate, Na 3 AlF 6 , as an Efficient Catalyst

Considerable attention has been focused on the synthesis of benzimidazoles due to having a broad spectrum of biological activities such as anti-parasitic, fungicidal, anti-thelemintic and anti-inflammatory activities. As a part of our research work in this area, a series of benzimidasole derivatives (3a-n) were synthesized in good to high yields by reaction of o-phenylenediamine and different a...

full text

A Simple, Efficient Synthesis of 2-Aryl Benzimidazoles Using Silica Supported Periodic Acid Catalyst and Evaluation of Anticancer Activity

A new, efficient method for the synthesis of 2-aryl substituted benzimidazole by using silica supported periodic acid (H5IO6-SiO2) as a catalyst has been developed. The salient feature of the present method includes mild reaction condition, short reaction time, high yield and easy workup procedure. The synthesized benzimidazoles exhibited potent anticancer activity against MCF7 and HL60 cell li...

full text

SnCl4/nano-sawdust as an Efficient Bio-based Catalyst for the Synthesis of 2-Substituted Benzothiazoles and Benzimidazoles

SnCl4/nano-sawdust was prepared as a carbohydrate-based catalyst containing of tin bearing cellulose units. The catalyst was characterized by X-ray diffraction (XRD), fourier transform infrared spectroscopy (FT-IR), field emission scanning electron microscopy (FESEM) and energy dispersive X-ray spectroscopy (EDS). The catalyst was applied successfully as a readily available, inexpensive, biodeg...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of pharmaceutical research

جلد ۱۳، شماره ۱، صفحات ۹۵-۱۰۱

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023